Endocrine Abstracts

Hypopituitarism and impaired fertility in adulthood may result from congenital genetic defects detected during childhood or acquired pituitary dysfunction after apoplexy or resection of a pituitary tumor or following radiation therapy. This lecture will review the fertility options for hypopituitary patients, success rates and predictors of outcome for conception and live births. In those with normal pituitary function planning surgery and/or radiation to the hypothalamic-pitu...

Adrenocortical carcinoma (ACC) is an aggressive malignancy with limited treatment options. We identified polo-like kinase 1 (PLK1) as one of the most overexpressed genes and potential drug target in ACC. PLK1 inhibitors (PLK1i) are under evaluation in clinical trials for other malignancies, being more effective in TP53-mutated tumours. Here we test PLK1i efficacy in four ACC cell lines with different genetic background. Efficacy of three PLK1i (i.e. Volaserti...